Plasmodium vivax in plasmodium ovale sporozoites enter into a dormant hepatic phase where they’re kind of hypnotized, they don’t divide instead they snooze for a period of time before entering the process of skits agony causing a long delay between the initial infection and symptoms from the disease, this is called the XO urine through siddik phase because it happens outside of the erythrocyte or red blood cell and it’s generally asymptomatic, the marisa lights are then released into the blood and each one binds to a surface receptor and invades a red blood cell, plasmodium ovale and plasmodium falciparum invade red blood cells of all ages whereas Plasmodium vivax prefers to invade reticulocytes which are young immature red blood cells. Plasmodium malariae and plasmodium Nala C prefer to invade older red blood cells, once inside the red blood cell the Marisa white undergoes a sexual reproduction and a series of transformational changes, this phase is known as the urethra siddik phase of malaria because it happens inside of the red blood cell and generally lasts two to three days in the first stage of the earth or acidic phase, the marrow ZOA, it looks like a tiny ring within the red blood cell and is called an early trophy xuit or a ring form in the second stage, the ring form trophies o8 grows and is referred to as a late trophies OA, in the third and final stage the parasite grows some more by digesting hemoglobin and leaves behind Hema xoan which under a microscope looks a little like a brown faeces smudge on a red blood cell, at this point the parasites called asked its aunt, this is the actual replicative phase in which the parasite undergoes mitosis and differentiates into lots of Marisa whites which can get released into the blood, you now instead of going into the Euro through civic phase again, some of the merits undergo gamete agony which is where they divide and give rise to comida sites which are little sausage shaped sexual forms that can be either male or female, these can be decides to remain inside of a red blood cell or could get sucked up by another female anopheles mosquito that might take a blood meal from the infected person.

The comida sites can then reach the mosquitos gut where they mature a bit more and then fuse together to form a zygote, this part of the plasmodium life cycle is called spur, a guinea and it’s sexual reproduction as opposed to skiz akane or asexual reproduction that happened in the liver and red blood cells. The zygote then goes on to develop further and it becomes an oaken eat and then an O cyst that ruptures in the mosquitos gut releasing thousands of sporozoites which navigate their way into the mosquitos salivary gland in order to repeat the cycle all over again, now the incubation time which is the period of time between infection and symptom onset varies, depending on the plasmodium species, plasmodium falciparum incubates for a few days, while plasmodium malariae incubates for a few weeks, the release of tumor necrosis factor-alpha and other inflammatory cytokines causes fevers that typically happens in paroxysms or short bursts and correspond to the rupture of the infected red blood cells which happens in waves of reproductive cycles, unique for each plasmodium species for plasmodium malariae fevers happen every 72 hours and is called a-courtin fever. For Plasmodium vivax in plasmodium ovale fevers happen every 48 hours and these are called tertian fevers, for plasmodium nala, the fever happens every 24 hours and for Plasmodium falciparum the pattern can vary sometimes following the pattern of a tertian fever while other times the fevers happen daily earning it the name malignant tertian fever in addition to fevers, the hemolytic anemia which is the destruction of red blood cells also causes symptoms like extreme fatigue, headaches, jaundice and splenomegaly most plasmodium infections have a mild course of symptoms and are generally regarded as uncomplicated malarial infections.

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